（中 文）感染与免疫应答

Teacher

Prof. Yuchen Xia, Prof. Shuliang Chen, Prof.   Rui Zhou, Prof. Xiaoming Cheng, Prof. Zhenping Ming; Prof. David Rollinson, Prof.   Xian-ming Chen, Prof. Kun Li, Prof. Markus Gerhard, Prof. Chunkyu Ko

First day of classes

2024.7.1

Last day of classes

2024.7.10

Course Credit

1

Course Description

Course Introduction

Pathogens,   including viruses, bacteria, fungi, and parasites, can cause severe health   issues, and negative impacts on economic growth as well as social stability.   This underscores the need for knowledge of infection mechanisms and their   outcomes. Infections and Immune Response intends to introduce students in   medical sciences, life sciences or other related disciplines to the variety   of infections and immune responses in humans.

Weekly   meetings will cover both classic and newly emerged infectious agents and   diseases, including HBV, HIV, Coronavirus, tumor virus, Helicobacter pylori,   malaria, schistosomiasis, Cryptosporidium and Cestode infection. Lectures   will be given by experts in these areas from Wuhan University, Technical   University of Munich (Germany), Cleveland Clinic Lerner College of   Medicine (US), Natural   History Museum (UK) and Rush University Medical Center (US), Korea Research Institute of Chemical Technology (Korea).

This   course focuses on infectious agents and interactions with host immune   responses and anti-infectives at the cellular and molecular level. It   consists of three main sections. (1) Viral infections: areas covered include   structure of pathogens, viral life cycle, pathogenesis and host immune   responses, diagnosis and treatments. Topics will be selected to present important   concepts in the context of infections or co-infections and host immune   responses and/or major challenges in controlling infections. Recent advances   in understanding virus-host interactions, host responses to infections,   global control strategies and elimination strategies will be emphasized. (2)   Bacterial infections: Helicobacter pylori will be considered as specific   examples, and how does Helicobacter pylori infect digestive tract and   modulate the composition of gastrointestinal microbiota will be discussed.   (3) Parasitic diseases: this course will systematically introduce the   mechanisms of infection, immune evasion strategies and pathogenesis. More   insight will be given into parasite-host interactions, epigenetic gene   regulation, and immune responses to parasites. The global challenges in the   field of treatment and control strategies will be also discussed.

Objective

At the completion of this   course, students will be able to：

· Master the basic knowledge of pathogens,   including the morphology, structure, functional activities, life cycles,   transmission/epidemiology, genetics, the prevention and treatment strategies   of infectious diseases.

· Explain the mechanistic/immunologic basis of   strategies employed by pathogens to evade the host defense systems.

· Gain an understanding of the molecular and   cellular mechanisms that underpin the pathogenesis and control of infections,   and the interaction of pathogens with the immune system.

· Demonstrate a global understanding of the   complexity of control and elimination of infections.

· Grasp recent advances in the progress of   pathogenic biology and gain a body of advanced research methods and   techniques in Microbiology, Virology, Parasitology and Immunology.

Assignments (essay or other forms)

Students need to write an essay in the interplay between host and   pathogen, no less than 1000 words.

Text Books and Reading Materials

· Principles of Molecular Virology, Alan J.   Cann, 6th Edition, 2015

· Principles and Practice of Infectious   Diseases, John E. Bennett, Raphael Dolin and Martin J. Blaser, 8th Edition,   2015

· Medical Immunology, Gabriel Virella, 7th   Edition, 2020

· Primary literature